Following various projects and internships in the CFD domain, I sought a more direct societal impact. This quest came to life during my undergraduate thesis in the Biophysics lab. I focused on creating a Python-based computational model to simulate hyperthermia treatment for cancer, aiming to mitigate the side effects of traditional cancer treatments. Our research on the targeted killing of tumor tissues while preserving healthy tissue is achieved by injecting carefully selected magnetic nanoparticles (MNPs) at the tumor site. By applying a varying magnetic field, the MNPs heated up, selectively raising the temperature of the tumor tissues and facilitating their elimination.
We meticulously discretized Penne's bioheat transfer equation using the Finite Difference Method, employing central difference and implicit time-stepping methods, ultimately solving the equations using TDMA and SOR methods. Beginning with a 1D model for skin cancer, we examined temperature variations over time and heat input. Subsequently, we expanded to a 2D model featuring square living tissues and tumors of varying sizes and numbers at different body locations, considering realistic boundary conditions like convection and adiabatic mirroring human body scenarios. Our observations included temperature distribution, necrosis time (time needed to eliminate tumor tissues), and ensuring the tumor tissue temperature reached 40°C while limiting temperature increases in healthy tissues.
In my bachelor's thesis, I faced a unique challenge that encouraged me to think beyond the realm of a mechanical engineer, adopting the perspective of a practicing physician combating cancer. This dual viewpoint has enriched my understanding and approach. Furthermore, this research experience has fortified my commitment to societal contribution by advocating for the widespread accessibility of microfluidic devices. Recognizing the challenges faced in underdeveloped countries due to limited resources, I aim to innovate devices tailored for low-resource settings. The global impact of the COVID-19 pandemic has underscored the critical need for self-testing kits and improved medical accessibility. I aspire to play a pivotal role in addressing these challenges and contributing to transformative change through my work.
One of the results of the two-dimensional case is shown below. Similarly, various test cases with different locations, sizes, and numbers of tumors exposed to different boundary conditions have been simulated. Since it is not yet published in a journal, all the simulation results are not displayed.
This is the computational domain with the tumor present at the center of the healthy tissue.
Boundary conditions:
The upper, left, and right surfaces are exposed to convection and the bottom surface is exposed to body core temperature
Necrosis time: 673.9 secs